meropenem bnf dose
Comments: Solutions prepared for infusion (MERREM IV concentrations ranging from 1 mg/mL to 20 mg/mL) re-constituted with Sodium Chloride Injection 0.9% may be stored for 1 hour at up to 25°C (77°F) or 15 hours at up to 5°C (41°F). Meropenem is cleared by haemodialysis and haemofiltration. The required dose should be administered after completion of the haemodialysis cycle. -For IV bolus: Constitute injection vials with sterile Water for Injection; shake to dissolve then let stand until clear. When only serum creatinine is available, the following formula (Cockcroft and Gault equation)1 may be used to estimate creatinine clearance. Re-constitute injection vials (500 mg and 1 gram) with sterile Water for Injection (see table 4 below). Medically reviewed by Drugs.com. The recommended dose of MERREM IV is 500 mg given every 8 hours for skin and skin structure infections and 1 gram given every 8 hours for intra-abdominal infections. -Do not operate machinery or motorized vehicles until it is reasonable well established that this drug is well tolerated. -Compatible for IV bolus: Sterile Water for Injection Abstract & Commentary . Available for Android and iOS devices. Weight (kg) × (140 - age) CrCl >60 mL/min: No dosage adjustment necessary; CrCl 21-60 mL/min: 260 mg/day PO; CrCl ≤20 mL/min or continuous peritoneal dialysis : 200 mg/day PO; Dosing Considerations Uses: As a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, S agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), P aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, Peptostreptococcus species, 1 g IV every 8 hours Use normal dose every 12 hours if eGFR 26–50 mL/minute/1.73 m 2. For pediatric patients weighing over 50 kg administer MERREM IV at a dose of 500 mg every 8 hours for cSSSI, 1 gram every 8 hours for cIAI and 2 grams every 8 hours for meningitis. NDA 50-706/S-022 Page 4 concentrations of meropenem in excess of … Hemodialysis, peritoneal dialysis: Data not available. -Pediatric patients younger than 3 months: Administer as IV infusion over 30 minutes. MERREM IV should not be mixed with or physically added to solutions containing other drugs. -General: Organ system functions (periodically during prolonged therapy) Urinary . Available for Android and iOS devices. Use half normal dose every 24 hours if eGFR less than 10 mL/minute/1.73 m 2. -Hematologic: Hematopoietic organ system functions (periodically during prolonged therapy) Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. -Recommended as empiric therapy of hospital-acquired pneumonia (including ventilator-associated pneumonia) and healthcare-associated pneumonia Complicated skin and skin structure infections, Infants less than 32 weeks GA and PNA less than 2 weeks, Infants less than 32 weeks GA and PNA 2 weeks and older, Infants 32 weeks and older GA and PNA less than 2 weeks, Infants 32 weeks and older GA and PNA 2 weeks and older, For pediatric patients 3 months of age and older, the MERREM IV dose is 10 mg/kg, 20 mg/kg or 40 mg/kg every 8 hours (maximum dose is 2 grams every 8 hours), depending on the type of infection (cSSSI, cIAI, intra-abdominal infection or meningitis). -Effective in eliminating concurrent bacteremia associated with bacterial meningitis. Typhoid Fever (Off-label) 15-20 mg/kg/day PO divided q12hr for 7-14 days. bolus, add 10 ml of sterile water for injection to 500 mg/20 ml vial size or 20 ml to 1 g/30 ml vial size to provide 50 mg/ml. Injection vials (500 mg and 1 gram) may be directly re-constituted with a compatible infusion fluid. • For pediatric patients weighing over 50 kg administer MERREM IV at a dose of 500 mg every 8 hours for cSSSI, 1 gram every 8 hours for cIAI and 2 grams every 8 hours for meningitis. Maximum dose: 2 g/dose Uses: As a single agent therapy for the treatment of complicated skin and skin structure infections due to S aureus (methicillin-susceptible isolates only), S pyogenes, S agalactiae, viridans group streptococci, E faecalis (vancomycin-susceptible isolates only), P aeruginosa, E coli, P mirabilis, B fragilis, Peptostreptococcus species, Less than 3 months: This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Maximum dose: 1 g/dose Solutions of intravenous MERREM IV should not be frozen. There is no accumulation of repeated doses of meropenem 500 mg every 8 hours, or 1 gram every 6 hours in patients with normal renal function. -Dry powder: Store at controlled room temperature 20C to 25C (68F to 77F) References. TDM-monograph Meropenem October 2015, CONCEPT version Page 4 of 5 meropenem 500 mg every 8 hours, or 1 gram every 6 hours in patients with normal renal function. -Shortening the duration of therapy may reduce the risk of superinfections with resistant organisms. Freshly prepared solutions of MERREM IV should be used. Manufacturer advises reduce dose to 0.5 g every 12 hours if creatinine clearance less than 10 mL/minute. See. Meropenem dose bnf Usage of meropenem Download Here Free HealthCareMagic App to Ask a Doctor. Maximum dose: 2 g/dose (See dosing table below.). Approximately 70% of the intravenously administered dose is recovered as unchanged meropenem in the urine over 12 hours, after which little further urinary excretion is detectable. 400 mg/day PO in single daily dose or divided q12hr. It is resistant to some forms of extended-spectrum beta-lactamase. Monitoring: Alternatively, an injection vial may be re-constituted, then the resulting solution added to an intravenous container and further diluted with an appropriate infusion fluid. Medically reviewed by Drugs.com. For pediatric patients (with normal renal function) less than 3 months of age, with complicated intra-abdominal infections, the MERREM IV dose is based on gestational age (GA) and postnatal age (PNA). -Hepatic: Hepatic organ system functions (periodically during prolonged therapy) He is also the Innovation Lead for the Australian Centre for Health Innovation at Alfred Health and Clinical Adjunct Associate Professor at Monash University.. It is given by injection into a vein.. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. -Compatibility with other drugs not established; this drug should not be mixed with or physically added to solutions containing other drugs. Source: Kuti JL, et al. -For IV infusion: May constitute infusion vials directly with compatible infusion fluid; alternatively, may constitute an injection vial, add the resulting solution to an IV container, then further dilute with an appropriate infusion fluid Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. -Adults: Administer by IV infusion over about 15 to 30 minutes; alternatively, doses of 1 g may be administered as an IV bolus injection over about 3 to 5 minutes. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. -Concentration of solution for IV infusion: Ranges from 1 to 20 mg/mL Comments: Directions for administration For continuous intravenous infusion , manufacturer advises reconstitute each 1 g (as meropenem) vial to produce a 0.05 g (as meropenem)/mL solution with 20 mL Sodium Chloride 0.9%. -Solution for IV infusion when constituted with Sodium Chloride Injection 0.9%: If unable to use freshly prepared solution immediately, may store for 1 hour at up to 25C (77F) or 15 hours at up to 5C (41F) All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. Doses of 1 gram may also be administered as an intravenous bolus injection (5 mL to 20 mL) over approximately 3 minutes to 5 minutes. -Infants less than 32 weeks GA and PNA 2 weeks or older: 20 mg/kg IV every 8 hours -Efficacy as monotherapy in the treatment of meningitis due to penicillin nonsusceptible isolates of S pneumoniae has not been established. Maximum dose: 1 g/dose Four hundred forty-six patients (397 pediatric patients 3 months to less than 17 years of age) were enrolled in 4 separate clinical trials and randomized to treatment with meropenem (n=225) at a dose of 40 mg/kg every 8 hours or a comparator drug, i.e., cefotaxime (n=187) or ceftriaxone (n=34), at the approved dosing regimens. Shake to dissolve and let stand until clear. 3 months or older: 10 mg/kg IV every 8 hours Acts by interfering with bacterial cell wall … Faropenem is an orally active beta-lactam antibiotic belonging to the penem group. Shake to dissolve and let stand until clear. Elimination half life (T 1/2): Table 3. The safety profile of meropenem in the elderly (aged > 65 years, n=843) and/or renally impaired (creatinine clearance < 51 ml/min, n=436) was assessed by evaluating data from 26 phase III studies which compared the use of meropenem (0.5 or 1.0 g, i.v. Dosing Modifications Renal impairment. Approximately 70% (50% to 75%) of a meropenem dose administered intravenously is recovered unchanged in the urine over 12 hours 1. See dosing table 2 below. Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections. Dosage should be reduced in patients with creatinine clearance of 50 mL/min or less. Table 1: Recommended MERREM IV Dosage Schedule for Adult Patients with Renal Impairment, Table 2: Recommended MERREM IV Dosage Schedule for Pediatric Patients 3 Months of Age and Older with Normal Renal Function, Table 3: Recommended MERREM IV Dosage Schedule for Pediatric Patients Less than 3 Months of Age with Complicated Intra-abdominal Infections and Normal Renal Function, Table 4: Volume of Sterile Water for Injection for Reconstitution of Injection Vials, We comply with the HONcode standard for trustworthy health information -, Recommended dose (500 mg cSSSI and 1 gram Intra-abdominal).
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